The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

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The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

This study has used biochemistry and real time confocal imaging of green fluorescent protein (GFP)-tagged molecules in live cells to explore the dynamics of protein kinase B (PKB) regulation during B lymphocyte activation. The data show that triggering of the B cell antigen receptor (BCR) induces a transient membrane localization of PKB but a sustained activation of the enzyme; active PKB is fo...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1999

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.145.7.1511